2021
Functional connectivity disturbances of ascending reticular activating system and posterior thalamus in juvenile myoclonic epilepsy in relation with photosensitivity: A resting-state fMRI study
Ur-Özçelik E, Kurt E, Şirin NG, Eryürek K, Ulaşoğlu-Yıldız Ç, Harı E, Ay U, Bebek N, Demiralp T, Baykan B.
Epilepsy Research
Resting-state functional connectivity alterations in drug-naive adolescents with obsessive-compulsive disorder
Kinay D, Ulaşoğlu Yıldız C, Kurt E, Eryürek K, Demiralp T, Coşkun M.
Psychiatry and Clinical Psychopharmacology
Prevalence of HIV-associated neurocognitive disorder (HAND) in Turkey and assessment of Addenbrooke's cognitive examination revised (ACE-R) test as a screening tool
Korten V, Ay U, Harı E, Tigen Tükenmez E, Gencer S, Akça Kalem S, Demirtaş Tatlıdede A, Gürvit İH.
HIV Medicine
Functional connectivity analysis in heterozygous glucocerebrosidase mutation carriers
Sezgin M, Kicik A, Bilgic B, Kurt E, Bayram A, Hanagası H, Tepgec F, Toksoy G, Gurvit H, Uyguner O, Gokcay G, Demiralp T, Emre M.
Journal of Parkinson's Disease
2020
The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI
Arslan DB, Gurvit H, Genc O, Kicik A, Eryurek K, Cengiz S, Erdogdu E, Yildirim Z, Tufekcioglu Z, Uluğ AM, Bilgic B, Hanagasi H, Tuzun E, Demiralp T, Ozturk-Isik E.
Journal of Neural Transmission
Functional neural substrates of football fanaticism: Different pattern of brain responses and connectivity in fanatics
Bilgiç B, Kurt E, Makar ÇC, Ulasoglu-Yildiz C, Samancı B, Gürvit H, Demiralp T, Emre M.
Psychiatry and Clinical Neurosciences
B-Tensor: Brain connectome tensor factorization for Alzheimer's disease
Durusoy G, Yildirim Z, Dal DY, Ulasoglu-Yildiz C, Kurt E, Bayir G, Ozacar E, Ozarslan E, Demirtas-Tatlidede A, Bilgic B, Demiralp T, Gurvit H, Kabakcioglu A, Acar B.
IEEE Journal of Biomedical and Health Informatics
White-matter changes in early and late stages of mild cognitive impairment
Femir-Gurtuna B, Kurt E, Ulasoglu-Yildiz C, Bayram A, Yildirim E, Soncu-Buyukiscan E, Bilgic B.
Journal of Clinical Neuroscience
Manyetik rezonans görüntüleme temelli fonksiyonel bağlantısallık yöntemleri
Hari E, Ay U, Nese H, Bayram A, Demiralp T.
İstanbul Tıp Fakültesi Dergisi
Functional connectivity analysis of patients with temporal lobe epilepsy displaying different ictal propagation patterns
Sirin NG, Kurt E, Ulasoglu-Yildiz C, Kicik A, Bayram A, Karaaslan Z, Bebek N, Baykan B, Demiralp T, Gurses C.
Epileptic Disorders
Evoked and induced EEG oscillations to visual targets reveal a differential pattern of change along the spectrum of cognitive decline in Alzheimer's disease
Tülay EE, Güntekin B, Yener G, Bayram A, Başar-Eroğlu C, Demiralp T.
International Journal of Psychophysiology
2019
Resting-state fMRI analysis in apathetic Alzheimer's disease
Büyükgök D, Bayraktaroğlu Z, Buker HS, Kulaksızoğlu MIB, Gurvit İH.
Diagnostic and Interventional Radiology
Measurement of cognitive dynamics during video watching through event-related potentials (ERPs) and oscillations (EROs)
Erdogdu E, Kurt E, Duru AD, Uslu A, Başar-Eroğlu C, Demiralp T.
Cognitive Neurodynamics
Intrinsic functional connectivity in social anxiety disorder with and without comorbid attention deficit hyperactivity disorder
Ergül C, Ulasoglu-Yildiz C, Kurt E, Koyuncu A, Kicik A, Demiralp T, Tükel R.
Brain Research
Neuroinflammation mediators are reduced in sera of Parkinson's disease patients with mild cognitive impairment
Kıçık A, Tüzün E, Erdoğdu E, Bılgıç B, Tüfekçıoğlu Z, Öztürk-Işik E, Hanağasi H, Gürvıt H.
Archives of Neuropsychiatry
Implicit contextual learning in spinocerebellar ataxia
Ulasoglu-Yildiz C, Gurvit H.
Neuropsychology
2017
A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology
Onay A, Yapıcı Eser H, Ulaşoğlu Yıldız Ç, Aslan S, Talı ET.
Diagnostic and Interventional Radiology
Evidence for alterations of the right inferior and superior longitudinal fasciculi in patients with social anxiety disorder
Tükel R, Ulasoglu Yildiz C, Ertekin E, Kurt E, Koyuncu A, Aydın K.
Brain Research
Cognitive and anatomical correlates of anosognosia in amnestic mild cognitive impairment and early-stage Alzheimer's disease
Senturk G, Bilgic B, Arslan AB, Bayram A, Hanagasi H, Gurvit H, Emre M.
Int Psychogeriatr
Fonksiyonel nörogörüntüleme
Sirin İnan NG, Bayram A, Kurt E., Demiralp T.
Türkiye Klinikleri
2016
Achromatic temporal-frequency responses of human lateral geniculate nucleus and primary visual cortex
Bayram A, Karahan E, Bilgiç B, Ademoglu A, Demiralp T.
Vision Research
Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine
Bilgiç B, Kocaman G, Arslan AB, Noyan H, Sherifov R, Alkan A, Asil T, Parman Y, Baykan B.
Cephalalgia
Determination of Multimodality Magnetic Resonance Imaging Based Biomarkers for Mild Cognitive Impairment in Parkinson Disease
Original Title: Parkinson Hastalığı Hafif Kognitif Bozukluğu İçin Multimodal Manyetik Rezonans Görüntüleme Temelli Biyoişaretleyicilerin Belirlenmesi
Principal Investigator: Esin Öztürk Işık, Institude of Biomedical Engineering, Bogazici University
Partners: Boğaziçi University, Istanbul University
Researchers:
Grant: 2015 TUBITAK 1001, # 115S219
Project Summary: The aim of this project is to identify biomarkers that would indicate the presence of mild cognitive impairment (MCI) and the probability of its evolution into dementia using machine learning algorithms, by evaluating the findings from multimodal MR imaging of patients diagnosed with PD-MCI, cognitively intact PD and healthy controls.
Integration of rs-fMRI, dMRI, ASL and MRSI data collected from patients with Parkinson’s disease (PD) and healty controls.
Another purpose of this project is to determine neuroimaging parameters which are correlated with different genotypes of COMT (catechol-O-methyltransferase) and MAPT (microtubule-associates protein tau), genes known to be assosciated with cognitive decline in PD.
Implicit Memory In Patients With Spinocerebellar Ataxia And Its Structural And Functional Connectivity Correlations
Original Title: Spinoserebellar ataksili hastalarda örtük bellek süreçleri ile yapısal ve fonksiyonel konnektivite korelasyonları
Principal Investigator: Prof. Dr. İbrahim Hakan Gürvit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University
Partners: Istanbul University
Researchers:
Prof. Dr. Haşmet Ayhan Hanağası,
Assist. Prof. Dr. Başar Bilgiç,
Assist. Prof. Dr. Aslı Demirtaş Tatlıdede,
Prof. Dr. Tamer Demiralp (Adviser)
Grant: TUBITAK 1001, # 115S437
Project Summary:
The aims of this project are (1) to investigate the intrinsic connectivity network (ICN) for implicit associative learning, and (2) to reveal how it is altered by cerebellar degeneration in spinocerebellar ataxia. We suggest that contribution of cerebellum to implicit associative learning is mediated through cerebello-striatal connectivity. Moreover, functional and structural connectivity between cerebellum and cerebral cortex with subcortical structures will be investigated.
Traditionally, cerebellum and basal ganglia were associated with only motor functions and considered as they were involved in both anotomically and functionally distinct systems. Accordingly, interactions between them could be only at the cortical level. On the other hand, accumulating information from neurosurgery, electroneurophysiology, neuropsychology and neuroanatomy studies reveal that cerebellum densely interacts with basal ganglia, and they each contribute cognitive processes. In addition to this, cerebellum and basal ganglia were separately associated with various forms of implicit learning. However, while the studies on SCA are mostly related with implicit motor learning, non-motor implicit associative learning has been neglected and its neural basis remained unlighted. Functional magnetic resonance imaging (fMRI) on implicit associative learning showed that hippocampal involvement in early stage of learning becoming increasingly dependent on basal ganglia with practice. Cerebellar involvement in implicit associative learning was also reported. Apart from the task-based studies, there is no study on resting state fMRI on SCA. While various ICNs have been defined such as visual, auditory, sensorimotor, language, sailence, episodic memory-self reflection network, any ICN for implicit associative learning has been suggested until now. This is the first time implicit associative learning has been described with subcortical connections and a corresponding ICN has been suggested. This will be the first study investigated non-motor implicit associative learning in SCA, and its correlations with structural and functional connectivity.
The project will be carried out with 20 patients with SCA, age, gender, education level-matched 20 healthy controls. All participants will complete a neuropsychological battery that assessed attention, memory, language, visuospatial functions, and executive functions and they will undergo diffusion tensor imaging and functional magnetic resonance imaging. Ataxia scores in patients will be evaluated with International Co-operative Ataxia Rating Scale. The ICN for implicit associative learning will be produced and how this ICN is altered by cerebellar degeneration will be shown.
We expect that outputs of this project will mediate the identification of ICNs for implicit learning, especially for implicit associative learning. If we can reveal the neural correspondence of implicit associative learning; it leads to clinical developments such as improving intact implicit memory abilities, taking advantage of this plasticity and planning rehabilitation (e.g. with repetitive transcranial magnetic stimulation [rTMS]) for various neurodegenerative disorders (e.g. Alzheimer disease) and/or seconder demential disorders (e.g. Korsakoff’s syndrome). In addition to this, the project will provide a better understanding for not only SCA but also basal ganglia and/or cerebellar dysfunction based diseases, and will shed light on investigation of feature treatment and rehabilitation plans.
